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Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC

While smoking marijuana has been associated with increased rates of adverse respiratory symptoms and chronic obstructive pulmonary disease 10,14 , it has not been conclusively linked to lung cancer 15

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